ABSTRACT
Objective:To compare the effects of desflurane and sevoflurane on cardiac electrophysiological balance in the patients undergoing gynecological surgery.Methods:Forty American Society of Anesthesiologists physical status Ⅰ or Ⅱ patients, aged 20-50 yr, weighing 46-73 kg, scheduled for elective gynecological surgery, were divided into sevoflurane group ( n=20) and desflurane group ( n=20) using a random number table method.Colloid solution was intravenously infused for volume expansion after entering the operating room.The patients were tracheally intubated after anesthesia induction and then mechanically ventilated.Sevoflurane group and desflurane group inhaled 1.3 MAC sevoflurane and desflurane, respectively, to maintain anesthesia.The 12-lead electrocardiograms were collected before anesthesia induction (T 1), at 5 min after tracheal intubation (T 2), and 20 min after the concentration reaching the preset concentration (T 3) to calculate QT interval, QTc interval, Tp-e interval, Tp-e/QT ratio and index of cardiac electrophysiological balance (iCEB) and to record mean arterial pressure (MAP) and heart rate (HR). Results:Compared with the baseline value at T 1, MAP was significantly decreased at T 2, 3, and HR was decreased, and QT interval and QTc interval were prolonged at T 3 in two groups, and the iCEB were significantly increased in sevoflurane group ( P<0.05). Compared with those at T 2, MAP was significantly decreased at T 3 in sevoflurane group, and HR and MAP were significantly decreased at T 3 in desflurane group ( P<0.05). The iCEB and Tp-e/QT ratio were significantly decreased and Tp-e interval was prolonged at T 3 in desflurane group when compared with sevoflurane group ( P<0.05). Conclusion:Desflurane has no marked effect on the cardiac electrophysiological balance, and sevoflurane causes a decrease in cardiac electrophysiological stability in the patients undergoing gynecological surgery.